The researchers found that the vitamin did not work at all in the absence of white blood cells, or in mice genetically lacking C/EBPe activity. The latter animals simply couldn’t respond to the vitamin. The researchers concluded that the vitamin appears to activate key pathways in your immune system to kill microbial invaders. Isn’t a turbo-charged immune system (toward invaders) what all of us want?
In this case, the researchers were studying a known genetic problem dealing with immunity. Niacinamide triggers expression of the gene (turns it on). Serendipitously, the researchers found that they could get the gene to over express with clinically achievable levels of the nutrient. And that made the immune cells go into a “feeding frenzy,” wiping out the foreign organisms. They became like sharks devouring a school of sardines.
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