Is This the Cause of Unwanted Weight Gain?

Dr. Frank Shallenberger, MD

February 4, 2019



Do you struggle with weight issues? If so, you’re not alone. There’s a reason this is a billion dollar industry – a lot of people can’t lose weight. No matter how hard they try. No matter what they eat. And no matter how much they exercise.

What most people don’t realize is that there’s an underlying cause of weight gain that might be keeping you from dropping those unwanted pounds. This cause can go hand-in-hand with a loss of muscle mass, so the effects can be dangerous to your overall health. Fortunately, it’s relatively easy to fix this underlying cause. As you’ll see, all you have to do is correct this one deficiency.

This overlooked cause of weight gain is simply a deficiency of amino acids. As you may know, amino acids are molecules that attach to each other in different sequences to make up the various proteins that regulate our bodies.

Does this mean you just have to take amino acids to lose weight? Well, there are two powerful research studies that indicate that a deficiency of amino acids may be one of the causes of an inability to lose weight.

Why Amino Acids Decrease Cravings

In the first study, a team of scientists from the University of Warwick in Coventry, United Kingdom decided to investigate how amino acids could result in weight loss. They start off their report by stating, “Amino acids have been long known to be the most efficient type of nutrient at satisfying hunger and providing an extended period of satiety.” Then, they go on to explain that the effect probably has to do with how amino acids directly act on the areas in the brain that control the feeling of hunger and cravings.

Previous studies have already shown that when researchers inject amino acids directly into the brains of rats, they don’t want to eat. So, how does it work? To find out, they conducted a series of experiments and discovered something that could transform our concepts about weight-loss practices.

The scientists, led by Nicholas Dale, a professor of neuroscience, found that a group of specialized brains cells called tanycytes are able to send signals that stop the sensations of hunger. Their findings were published in the journal Molecular Metabolism. They were able to show that the tanycytes start sending anti-hunger signals when they detect certain amino acids in the blood.

Professor Dale had this to say about the findings, “Amino acid levels in blood and brain following a meal are a very important signal that imparts the sensation of feeling full. Finding that tanycytes, located at the center of the brain region that controls body weight, directly sense amino acids has very significant implications for coming up with new ways to help people to control their body weight within healthy bounds.” Well, that’s great for rats, but what about people?

Blood Levels of Amino Acids Affect Appetite

Back in 1997, scientists from the Department of Medicine at UCLA School of Medicine, published a report entitled, “Relationship between serum amino concentration and fluctuations in appetite.” In that study, the researchers looked at the blood levels of amino acids after a group of men and women ate meals composed of various amounts of amino acids. Then, they asked the participants on a scale of zero to four how hungry they were. They discovered that the higher the blood (serum) levels of amino acids were, the less hunger the men and women felt. But what if there was something else in the food that decreased appetite? Maybe it wasn’t the amino acids?

In two other experiments, instead of having the subjects eat the amino acids in the form of foods, they infused them directly into the veins.  And in a forth experiment they had the subjects drink a solution of pure amino acids in the absence of any food.  Here’s what they discovered.

“In all four experiments the appetite diminished when the amino acid concentration rose, and when the amino acid concentration fell, the appetite increased.” This is called a “dose responsive pattern.” As I have pointed out many times before, a dose responsive pattern is proof that the substances being tested, in this case amino acids, are responsible for the results.

But Does It Work in Real Life?

They do, in fact, decrease the appetite. Just ask Carly and Walter. I have been helping Carly and Walter stay healthy and feel great for years. Recently, they read my report on Perfect Amino and, on their own, started taking it every day. They just sent me the following email:

“Hi Dr. Shallenberger, Happy New Year!

“Walt and I started taking Advanced Bionutritionals’ Perfect Amino after reading the article and watching the video. What we've discovered is that we're losing weight and body fat very steadily!

“I started taking six tablets first thing every morning along with my thyroid medication about eight weeks ago. I've found my appetite has dropped and when I eat, small amounts are just fine – with almost no craving for sweets!

“In this eight weeks, I've dropped from 143 to 132; and that's with slacking on my three days a week at the gym over the holidays! Walt has had similar results with taking 10 tablets every day; he's also lost over 10 pounds. Is this okay? The video said we might gain weight?

“We feel good – and certainly like having excess fat go away! But it's been a steady, fairly rapid loss and it's continuing.... We were following the doc’s dosage advice from the video. However, the directions on the bottle are to take five tablets as a supplement, and five to ten as an exercise aide. Should we cut back when reaching a certain weight?”

My response was that that any weight loss while taking Perfect Amino could never be from loss of muscle mass. I have already reported on a study that found that even when people are placed on a very low calorie diet for weeks, they will not lose lean body mass if they are taking the amino acid blend found in Perfect Amino. The weight loss that Walt and Carly were experiencing was strictly due to fat loss. And, that’s a good thing. Any treatment that increases fat metabolism is a healthy treatment.

The weight gain I referred to in the video was muscle mass weight gain. And even when there is some weight gain from increasing muscle mass, it’s often much less than the decrease in weight from fat loss. Which explains why the numbers on the scale often go down instead of up.

So, if you struggle with controlling your weight because you are just too hungry, it may be that you’re amino acid deficient. In that case, take five to ten tablets (or one to two scoops) of Perfect Amino one to two times a day.

Try This Along With the Amino Acids

In addition to the amino acids, try intermittent fasting. It’s not only a great way to control weight, but it is also a very healthy habit.

Pick one day of the week, and skip lunch and supper on that day.  Instead of food, drink two quarts of water with fresh lemon juice.  You can also have coffee or tea. Add to this two scoops or 10 tablets of Perfect Amino twice a day. If you’re anything like Carly and Walt, you will not feel hungry even though you’re not eating. And remember, that since the special blend of amino acids in Perfect Amino are not metabolized into energy, they offer no net calories.

If you decide to try this, let me know how it works for you. I’ve got a feeling that Professor Dale might be right when he suggests that amino acids may be crucial for many people when it comes to appetite control. And, I can’t think of a better blend of amino acids than what we have in Perfect Amino. If you haven’t seen the video Carly was referring to, you can see it by following this link.


Mellinkoff SM, Frankland M, et al. Relationship between serum amino acid concentration and fluctuations in appetite. Obes Res. 1997 Jul;5(4):381-4.

Lazutkaite G, Soldà A, et al. Amino acid sensing in hypothalamic tanycytes via umami tastereceptors. Mol Metab. 2017 Nov;6(11):1480-1492.


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