You probably already know that inflammation, particularly chronic inflammation, is a major player in many diseases. This includes cancer, cardiovascular disease, and type-2 diabetes. However, while prolonged inflammation is detrimental to our health, it's important to keep in mind that inflammation is ultimately a function of the immune system designed to protect us. And new research out of the Joslin Diabetes Center has discovered a new way even chronic inflammation does just that for people with type-2 diabetes.
You might be surprised to learn that cardiovascular disease is actually the leading cause of death among people with type-2 diabetes. But this makes more sense when you realize that the high levels of glucose, cholesterol, and triglycerides associated with type-2 diabetes trigger white blood cells called monocytes to enter artery walls. There they turn into cells called macrophages that suck up fats. Unfortunately, these cells stay stuck in the arteries, clogging them up and leading to atherosclerosis. Then the glucose and lipids turn on a molecule called protein kinase C (PKC), which contributes to activating the macrophages, making inflammation even worse.
However, not all PKC molecules are created equal. The researchers discovered that one form, called PKC-delta, actually helps reduce the macrophage population, suppressing inflammation. The researchers, who admitted to being shocked by the discovery, published their findings in Circulation Research. As they continued to investigate, they found that high lipid levels are responsible for triggering the production of PKC-delta to fight inflammation.
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The researchers are hopeful that they may be able to directly activate PKC-delta to reduce the monocyte population and control inflammation. However, because PKC-delta has different effects throughout the body, it may be challenging to target it specifically in artery walls.
While the researchers have a journey ahead of them before they can utilize PKC-delta in treatment, it's always reassuring to know that our bodies have mechanisms to fight for us, not just against us, when our health is in trouble. And I do think they are on the right track by seeking ways to fight inflammation.
One of my favorite ways to do that is with Reduloxin, a powerful anti-inflammatory supplement that contains a blend of nine herbs and nutrients that support a healthy immune response. However, I think that inflammation is only one piece of the puzzle when it comes to treating type-2 diabetes. I've written about the rest of the process in my book The Type-2 Diabetes Breakthrough. If you or a loved one has type-2 diabetes, is at risk of type-2 diabetes, or wants to avoid it altogether, this book is for you. It includes information about sleep, diet, lifestyle choices, and more to help you address or avoid this disease.
Yours for better health,
Frank Shallenberger, MD